lol thanks, its mostly just the way the program operates, really
On booting it up, the 4 things I always do on turning on are:
ctrl + f: full screen it immediately.
Style (far left button) -Click to switch to the fat line. By default it's set to line, but that's no fun. Click on it to set it to shapes, its like having a weird version of the lasso tool that auto fills.
Affects -Gradient -Smooth Gradient creates tone shifts, while smooth repeatedly tightens every stroke you've done whenever you put a new stroke anywhere. The two turned on just lets you get away with goofs. Mirror is the only other affect I mess with regularly, the rest are stuff I'm still trying to figure a way to implement without too much chaos.
Afterwards, just go wild in black and white. Same as photoshop, 'X' is the hotkey to switch between your current colors, and for me I just stick with black and white. White is really your only 'erase' tool, but should be treated more like how you'd use an eraser in real life than a digital eraser, if that makes sense.
The trick to Alchemy for me is to treat it like sketching. A lot of the finer details I just stroked the same way I'd do a stroke with a normal pencil, and just constantly refining by switching between black and white.
When making new limbs on a person, I start by blocking in a silhouette in black, establish core lights in white, then just keep switching between black and white while stroking in a shade. That's pretty much it.